The assessment of Anti-diabetic and Anti- Inflammatory Activities Using crude extract of Acacia nilotica

Authors

  • Raisham Raisham Department of Chemistry University of Swabi
  • Muhammad Ibrahim Department of Chemistry University of Swabi
  • Muhammad Ismail Department of Botany University of Swabi
  • Abdur Rahman Department of zoology, Abdul Wali Khan University Mardan
  • Muhammad Umar Department of zoology, Abdul Wali Khan University Mardan
  • Hajrah Abid Siddiq Government college University Faisalabad, Punjab, Pakistan
  • Iraj Hameed Department of zoology, Abdul Wali Khan University Mardan

Keywords:

Anti-diabetic and Anti- Inflammatory, plant extract, Acacia nilotica

Abstract

Diabetes mellitus, which can be inherited or acquired, is a chronic disease caused by insufficient or ineffective insulin production by the pancreatic beta cells. High blood glucose levels lead to insulin insufficiency, which damages several bodily systems, most notably the neurological and cardiovascular systems. Inflammation is a critical response initiated by immune system of the body to fight infections. But prolonged and abandoned inflammation causes problems such as diabetes, cancer and cardiovascular complications. Now its treatment plays an important role for current era researchers. As the imitated drugs like diclofenac sodium and diclofenac potassium have high inflammatory potential but they can result in intestinal distension, flatulence, nausea and diarrhea. Therefore, plants extract with slight or no side effects are used as inflammatory medications. Acacia nilotica is an essential medical plant of the world used in traditional treatment of many diseases such as inflammation, skin outbreaks, blisters, swellings and spots. In this study Acacia nilotica extract was investigated for its anti-diabetic and anti-inflammatory properties. Acacia nilotica extract was checked by performing anti-diabetic assay Glucose uptake by yeast cells assay (57 % at 80µg/ml) and its anti-inflammatory properties by membrane stabilizing assay of red blood cells (70.07 % at 100µg/ml). Significant activities were shown by each one which gave substantial results, providing the importance Acacia nilotica extract therapeutically. Much more studies and research are needed in this aspect, to look for medicinal properties in our local substances and find out the hidden treasures of substances used traditionally over the years.

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Published

2023-12-30

How to Cite

Raisham , R., Ibrahim , M., Ismail , M. ., Rahman, A. ., Umar, M. ., Siddiq, H. A., & Hameed, I. (2023). The assessment of Anti-diabetic and Anti- Inflammatory Activities Using crude extract of Acacia nilotica . Phytopharmacology Research Journal, 2(3), 28–33. Retrieved from http://ojs.prjn.org/index.php/prjn/article/view/55