Phytopharmacology Research Journal http://ojs.prjn.org/index.php/prjn <p><strong>Welcome to </strong><strong>Phytopharmacology Research Journal (PRJ)</strong></p> <p>Phytopharmacology Research Journal (PRJ) is an international open-access peer-review journal committed to publishing review articles, editorial letters, full-length research papers, short communications, and mini-reviews thrice a year.</p> <p><strong>Article processing changes</strong></p> <p>Phytopharmacology Research Journal (PRJ), is an international open-access peer-review journal committed to publishing high quality articles which provide free access to readers. In order to cover the charges of editing, typesetting, formatting, review process, management of journal, and an article processing charge (APC) 300 dollars applies to MS consider for publication.</p> <p><strong>Publishing address</strong></p> <p>Phytopharmacology Research Journal (PRJ), a publication office of Advance Research and Education Center (SMC-PRIVATE) Limited, Rashid Abad, Madina Colony, Street # 7, Office No. 1 Near Dispensary Canal Road, Peshawar, KP, Pakistan. is an international open-access peer-review journal committed to publishing review articles, editorial letters, full-length research papers, short communications, and mini-reviews thrice a year. </p> en-US editorinchief@prjn.org (Dr. Abdur Rauf) engr.sulaiman.khan3@gmail.com (Engr. Sulaiman) Mon, 08 Jan 2024 07:59:04 +0000 OJS 3.3.0.7 http://blogs.law.harvard.edu/tech/rss 60 GC-MS analysis, antimicrobial, antioxidant, phytochemical, and phytotoxic activities of Elaeagnus angustifolia L. using different extracts http://ojs.prjn.org/index.php/prjn/article/view/49 <p>This study aimed to assess the phytotoxic, phytochemical, antioxidant, and antibacterial properties of <em>Elaeagnus angustifolia</em>, a therapeutic plant. As solvents, distilled water, methanol, and ethanol were used to make the plant extracts. Using the DPPH free radical scavenging activity, the antioxidant activity was ascertained, and the IC<sub>50</sub> was calculated. The ethanolic extract of <em>Elaeagnus angustifolia</em> had 0.90±0.16 total flavonoid components, whereas the methanolic and aqueous extracts were found to contain 0.78±0.16 total phenolic contents. At 1.5 mg/ml, the antioxidant findings of <em>Elaeagnus angustifolia</em>'s methanolic extract showed 0.78±0.18 percent inhibition and SCV 49.10%, while the ethanolic extract showed 0.54±0.12 percent inhibition with 64.28% SCV. The best-result-oriented <em>Elaeagnus angustifolia</em> extract underwent phytochemical analysis using the Gas Chromatography-Mass Spectrometry (GC-MS) method. The findings showed that a variety of compounds were present, with the most common ones being acetone (1.18%), ethyl acetate (38.95%), isobutyl acetate (2.71%), Phytol (3.57%), isoquinoline,1-[(3,4-diethoxyphenyl)methyl].n-Hexadecanoic acid (5.61%), 9-Octadecenoic acid, 1,2,3-propanetriyl ester (10.72%), Bis(2-ethylhexyl) phthalate (3.48%), Squalene (1.40%), Octadecanoic acid (1.78%), n-propyl acetate (4.09%), 2,2-Dimethyl-3-(3,7,16,20-tetramethyl (1.12%) and 1,6,10,14,18,22- Tetracosahexaen-3-ol (1.195%). In order to determine the phytotoxic potential of <em>Elaeagnus angustifolia</em> leaf and stem extracts, a growth bioassay was performed against Lemna minor. The current study demonstrated that in order to create efficient management strategies that drastically lessen the influence of the infections on both human health and the environment.</p> Aiman Laraib Syed, Ghulam Mujtaba Shah, Saleha Ashfaq, Hafsa Abrar, Noor e Baseerat, Naqash Khan, Muhammad Hamza, Muhammad Abbas Hasan, Kareem Ullah, Kareem Ullah Copyright (c) 2023 Phytopharmacology Research Journal http://ojs.prjn.org/index.php/prjn/article/view/49 Sat, 30 Dec 2023 00:00:00 +0000 Phytochemical and Pharmacological Studies on Euphorbia pulcherrima: A Review http://ojs.prjn.org/index.php/prjn/article/view/56 <p>Euphorbiaceae, often known as the "Euphorbias or spurge family," constitutes a large family of 300 genera and 5000 species; spread widely around the world. The genus is particularly known for its secretion of secondary metabolites. Phytochemical investigation showed the presence of water-soluble ash (2.5%), methanol soluble ash (0.13%), acid insoluble ash (2.2%) besides total ash value (3 %); illustrating the presence of 3% carbonate, phosphate, and silicates of sodium, calcium, phosphates, and magnesium on the incineration of <em>E. pulcherrima</em>. The leaves extract showed potential antimicrobial capacity at 10 mg/100 µL and 20 mg/100 µL. <em>E. pulcherrima</em> possesses characteristic antimicrobial, antioxidant efficacy, and anti-convulsant effect because of its phytochemical content. The presence of patuletin, flavonoids, and spinacetin further imparts anti-inflammatory tendency as evidenced by the decrease in edema in rats' feet, analgesic and sedative effects.</p> Nabia Hafeez Copyright (c) 2023 Phytopharmacology Research Journal http://ojs.prjn.org/index.php/prjn/article/view/56 Sat, 30 Dec 2023 00:00:00 +0000 Qualitative phytochemical analysis of stem, leaves and fruits of Withania somnifera L. in different solvents http://ojs.prjn.org/index.php/prjn/article/view/60 <p><em>Withania somnifera </em>L. member of family Solanaceae abundantly found in sub-tropical regions of the world, it is a multipurpose medicinal plant. Phytochemical screening of <em>Withania somniferra </em>L. was carried out to know about the medicinal potential of same plant. A qualitative analysis was performed to detect various bioactive compounds. The stem, leaves and fruits were individually subjected to phytochemical analysis, revealing the presence of carbohydrates, alkaloids, saponins, flavonoids. proteins, Anthocyanin, Quinones and Tanins which enable it for the developing of new drugs.</p> Muhammad Niaz, Hafsa Abrar, Ramla Jadoon, Kinza Akram, Hajra Qayyum, Saleha Ashfaq, Naqash Khan, Syed Asad Abbas, Aamir Sultan Copyright (c) 2023 Phytopharmacology Research Journal http://ojs.prjn.org/index.php/prjn/article/view/60 Sat, 30 Dec 2023 00:00:00 +0000 Qualitative phytochemical analysis of rhizomes and roots extracts of Bergenia ciliate http://ojs.prjn.org/index.php/prjn/article/view/61 <p>The purpose of this study was to investigate the phytochemical constituents of <em>Bergenia ciliata</em> extracts and evaluate their potential biological activities. The extracts were exposed to qualitative phytochemical screening, revealed the presence of tannins, phenols, carbohydrates, saponins, oxalates, anthocyanins, cardiac glycosides, reducing sugars, coumarins, and alkaloids. These findings suggest that <em>Bergenia ciliata</em> possesses a wide range of bioactive compounds that may be involved to its observed medicinal properties. Further research is required to determine the pharmacological potential of these compounds, isolate them, and characterize their specific bioactivities that serves as their therapeutic effects.</p> <p> </p> <p> </p> Muhammad Niaz, Hajra Qayyum, Hafsa Abrar, Ramla Jadoon, Saleha Ashfaq, Noor e Baseerat, Naqash Khan, Bushra Bibi Copyright (c) 2023 Phytopharmacology Research Journal http://ojs.prjn.org/index.php/prjn/article/view/61 Sat, 30 Dec 2023 00:00:00 +0000 The assessment of Anti-diabetic and Anti- Inflammatory Activities Using crude extract of Acacia nilotica http://ojs.prjn.org/index.php/prjn/article/view/55 <p>Diabetes mellitus, which can be inherited or acquired, is a chronic disease caused by insufficient or ineffective insulin production by the pancreatic beta cells. High blood glucose levels lead to insulin insufficiency, which damages several bodily systems, most notably the neurological and cardiovascular systems. Inflammation is a critical response initiated by immune system of the body to fight infections. But prolonged and abandoned inflammation causes problems such as diabetes, cancer and cardiovascular complications. Now its treatment plays an important role for current era researchers. As the imitated drugs like diclofenac sodium and diclofenac potassium have high inflammatory potential but they can result in intestinal distension, flatulence, nausea and diarrhea. Therefore, plants extract with slight or no side effects are used as inflammatory medications. <em>Acacia nilotica </em>is an essential medical plant of the world used in traditional treatment of many diseases such as inflammation, skin outbreaks, blisters, swellings and spots. In this study <em>Acacia nilotica </em>extract was investigated for its anti-diabetic and anti-inflammatory properties. <em>Acacia nilotica</em> extract was checked by performing anti-diabetic assay Glucose uptake by yeast cells assay (57 % at 80µg/ml) and its anti-inflammatory properties by membrane stabilizing assay of red blood cells (70.07 % at 100µg/ml). Significant activities were shown by each one which gave substantial results, providing the importance <em>Acacia nilotica</em> extract therapeutically. Much more studies and research are needed in this aspect, to look for medicinal properties in our local substances and find out the hidden treasures of substances used traditionally over the years.</p> Raisham Raisham , Muhammad Ibrahim , Muhammad Ismail , Abdur Rahman, Muhammad Umar, Hajrah Abid Siddiq, Iraj Hameed Copyright (c) 2023 Phytopharmacology Research Journal http://ojs.prjn.org/index.php/prjn/article/view/55 Sat, 30 Dec 2023 00:00:00 +0000