Protective effects of Mentha longifolia Methanolic Extracts on Renal biomarkers and Histo-physiology in Paracetamol-intoxicated Rabbit

Abstract

The present study was designed to investigate the effect of 14 days orals administration of Mentha Longifolia methanolic extract on kidney related hematology and histopathology of Kidney in paracetamol intoxicated rabbits. Total of 25 rabbits were randomly divided into five groups (each group containing five rabbits) including normal group, toxic group (paracetamol treated 2g/kg), low group (100mg/kg), median (200mg/kg) and high group (300mg/kg) after paracetamol intoxication. During the present study, administration of high doses of paracetamol significantly increases the level of Urea and creatinine. The methanolic extract of Mentha longifolia significantly decreases the level of Urea and creatinine is compared to paracetamol group. The hematological parameters investigated during the present research were improved with the treatment of Mentha longifolia methanolic compared with paracetamol intoxicated rabbits. In addition, histopathological assessment of the kidney of different groups was performed. The kidney of paracetamol intoxicated rabbits was seriously affected compared to normal. The methanolic extract actively recovered the aforementioned toxicity in various groups.