Anti-diabetic and Anti- Inflammatory activities of Melia azedarach extract

Abstract

Diabetes mellitus is a metabolic disorder marked by persistently high blood glucose levels, which may result in significant morbidity and mortality. Individuals who are diagnosed with diabetes must take insulin for the rest of their lives and may experience several disease-related complications. Inflammation is considered a root of many disorders; it amplifies the production of electrons which results in higher production of oxygen reactive species. This leads to chain reactions that cause a great deal of ailments, including diabetes, cancer, and cardiovascular issues. Natural substances are way better than pharmaceutical drugs as they have many side effects along with curative properties. Plant extract and their secondary metabolites have traditionally been used in ethno-medicine to treat a variety of diseases. The primary objective of this study was to assess the anti-diabetic and anti-inflammatory effects of Melia azedarach extract. The anti-diabetic activity was evaluated using the glucose uptake by yeast cells assay, which demonstrated 70.03% activity at a concentration of 100 µg/ml. Additionally, its anti-inflammatory potential was examined through the red blood cell membrane stabilizing assay, yielding a result of 71.95% at 100 µg/ml. All these anti-diabetic and anti-inflammatory assays have revealed noteworthy results that support the traditional use of Melia azedarach as medicine. However, further in vivo study is needed with the extract of Melia azedarach its therapeutic effect against diabetes mellitus and Inflammation.