Anxiolytic and Antidepressant Like Effects of a Novel Synthetic Compound in Animal Models

Abstract

A significant number of people suffer from anxiety and depression, which are two of the most common mental health conditions. Even while first-line anxiolytic and antidepressant medicines have been shown to be effective, their serious side effects frequently lead people to look for alternative therapies due to their potential therapeutic profile. The potency, efficacy, wide pharmacological activity, and reduced side effects of trisamine-based medications have attracted attention in the modern medicine. Because of their potential therapeutic characteristics, they are a safer, more effective, and more economical option for treating mental health concerns. This study evaluated the neuropharmacological potential of trisamine derivatives, emphasizing its sedative, anxiolytic, and antidepressant qualities.Several behavioral models were used to screen the selectedcompound, and the results were noteworthy.In an open field test, compound Z-1 demonstrated potent sedative action at every tested dosage.In behavioral tests, it also showed quite significant (***P<0.001) anxiolytic effects. Compound Z-1 demonstrated potent antidepressant effect in the forced swimming test (FST).Strong neuropharmacological effects were shown by the chosen compound.