Anxiolytic and Antidepressant Effects of a Tris(2-aminoethyl)amine Derivative: A Preclinical Study

Abstract

Anxiety and depression are among the most prevalent mental health disorders, affecting a vast portion of the population. Despite the well-established efficacy of first-line anxiolytic and antidepressant treatments, their significant side effects often drive individuals to seek alternative therapies. Trisamine-based drugs have drawn interest in the modern age because of their potency, efficacy, broad pharmacological activity, and decreased adverse effects. They are a safer, more effective, and more affordable option for treating mental health issues because of their promising therapeutic profile. Trisamine derivatives' neuropharmacological potential was assessed in this study, with a focus on their sedative, anxiolytic, and antidepressant properties. The chosen compound was screened using a variety of behavioral models, and the results were significant. Compound N-1 showed very less sedative activity at highest tested dose in open field test,.however it demonstrated highly significant (***P< 0.001) anxiolytic effects in behavioral assessments. Although forced swimming test (FST), compound N-1 proved some activity at highest tested dose, the activity become decreased with decrease in dose which shows it has dose dependant antidepressant activity.The selected compounds exhibited strong neuropharmacological effects.