Phytochemical Screening, Pharmacological Profiling and Identification of Potential Therapeutic Applications of Rosa multiflora

Therapeutic Applications of Rosa Multiflora

Abstract

The pharmacological screening of plant products gained significant attention against disease causing microbes and oxidative damage of free radicals. The current attempt was aimed to screen out phytochemicals, pharmacological and antioxidant potential of the Rosa multiflora.  Phytochemical screenings of leaves revealed the presence of carbohydrates, proteins, phenols, flavonoids, tannins, and saponins. FTIR analysis of leaf powder revealed the existence of aldehyde/ketone functional groups, evident from the C=O stretch at 1719 cm^-1 indicating the presence of aldehyde compounds. Spectral analysis confirmed the presence of major functional groups of aldehyde/ketone(C=O), phenol (OH) and polysaccharides. The ethanolic crude extract of leaf was tested for antioxidant, antibacterial, and antifungal potential. The extract was found effective against Enterobacter aerogenes (13.76±0.51mm), followed by Pseudomonas aureus (12.37±0.55mm), Streptococcus aureus (11.06±1.05mm), Bacillus subtilis (10.96±0.45mm), Escherichia coli (9.1±0.66mm) and Salmonella typhi (8.7±0.52mm) at dose of 20mg/ml. The extract was found effective against bacteria, specifically at a concentration of 20mg/ml. The antifungal activities show that crude extract of leaf was effective against Aspergillus nigar (7.33±1.35mm) followed by Aspergillus fumigatus (6.86±1.8mm) and Aspergillus flavus (6.16±1.26mm), indicating that leaf extract effectively inhibits the growth of these fungal strains. The antioxidant potential of the plant leaf extract was evaluated using a DPPH (2, 2-diphenyl-1-picrylhydrazyl) radical scavenging assay. The extract exhibited significant activity at a concentration of 62.5mg/ml with 76.53% inhibition. In comparison, Vitamin-C (ascorbic acid) demonstrated 100% inhibition at the same concentration. The selected plant potential of could prove ground-breaking for pharmaceutical industry, researchers and scientific community for further research in this area.